The major challenge in current humanitarian assistance/disaster relief (HA/DR) efforts is that diverse information and knowledge are widely distributed and owned by different organizations. These resources are not efficiently organized and utilized during HA/DR operations. We present a knowledge management framework that integrates multiple information technologies to collect, analyze, and manage information and knowledge for supporting decision making in HA/DR. The framework will help identify the information needs, be aware of a disaster situation, and provide decision-makers with useful relief recommendations based on past experience. A comprehensive, consistent and authoritative knowledge base within the framework will facilitate knowledge sharing and reuse. This framework can also be applied to other similar real-time decision-making environments, such as crisis management and emergency medical assistance.