This paper aims at assessing the feasibility and appropriateness of Cash Transfer Programming (CTP) within the operational areas of International Orthodox Christian Charities (IOCC) and their humanitarian response activities to the refugees and migrants’ crisis on the Greek islands of Chios and Kos. Awareness about the limitations of traditional in-kind aid, in an unusual humanitarian setting with a highly mobile target group, has led to commissioning this paper; IOCC aims at informing their decision about a potential programmatic shift in their way of delivering humanitarian assistance by making use of CTP.