With the deteriorating humanitarian situation in Syria and the broader Middle East in mind, this report investigates how past examples of regional responses to humanitarian crises have succeeded or failed to meet humanitarian objectives, in order to inform responses to contemporary crises. Second, and as importantly, it assesses whether such regional responses contributed to strengthening regional integration and cooperation, paving the way for increased regional stability and an improved capacity to respond to emergencies. The report looks at two very different humanitarian crises: the war in the former Yugoslavia in the 1990s and Cyclone Nargis in Myanmar in 2008, respectively. It explores the ways in which countries in each region and regional organizations addressed humanitarian needs. The last section then draws lessons from these past experiences that could be applied in contemporary crises, especially the one in Syria.