The Global Alliance on HIV was launched in the Americas in July 2008 as an enabling framework to support National Societies (NSs) to significantly scale up their resources and capacities in responding to HIV, building partnerships and collaborations in order to maximize their contribution to worldwide efforts to combat the disease and the stigma and discrimination that surrounds it. At the end of the four-year programme, an evaluation was commissioned to document good practices and lessons learned, evaluating the impact of the Global Alliance on HIV in the Americas and make recommendations.