Global chemical sales are predicted to grow by about 3 percent per year until 2050, the major part of which will take place in Asia. Many countries in Southeast Asia lack the capacity to handle chemicals management and are in great need to develop institutions, legislation, knowledge and awareness around the issues. The programme “Towards a Non-Toxic Environment in South-East Asia” aimed to reduce health and environmental risks by monitoring, regulating and managing agricultural, industrial and consumer chemicals. This evaluation assesses FAO’s role and contributions to the programme, including work on gender mainstreaming, communication and follow-up actions taken in response to the 2016 mid-term evaluation.