Between 2015 and 2019, CARE has run 57 projects that aimed to stop the spread of infectious disease epidemics — like Ebola, cholera, and zika — in 20 countries around the world. These projects collectively worked with 9 million people directly and 16.7 million indirectly. This document draws lessons from CARE’s response to some of the most severe epidemics in recent memory to inform COVID-19 response.