The Global Framework for the Control of Transboundary Animal Diseases (GF-TADs) is a joint governance mechanism of FAO and the World Organisation for Animal Health (OIE) launched in 2004 to achieve coordinated prevention and control of transboundary animal diseases (TADs), and in particular to address their regional and global dimensions. This is the third evaluation of the GF-TADs and covers the period from 2009 to 2017. The evaluation aims to provide the GF-TADs Global Steering Committee and Management Committee with lessons learned and evidence which can be used to inform its future strategic development by providing recommendations to guide GF-TADs’ enhanced collaboration at regional and global levels and encourage improvement of the GF-TADs’ tools. The evaluation examined the added value of the GF-TADs as a mechanism to facilitate collaborative work between FAO, OIE and TADs partners in addressing global risks from TADs.