In order to inform the Bangladeshi Government’s COVID-19 response and that of its humanitarian and development partners in Cox’s Bazar, it is essential to supplement the existing evidence base with a focus on adolescent girls and boys, given the likelihood that containment measures will have multidimensional effects on young people’s well-being in the short and medium term. This policy brief draws on virtual research findings carried out with adolescent girls and boys in May and June 2020 and also presents priority policy and programming implications.