South Asia is at a crossroad of the cascading risks emanating from the rapid spread of the Coronavirus Disease-19 (COVID-19) and climate extremes in monsoon months. Every year, people in the subregion suffer from various climate hazards such as floods, droughts, tropical cyclones and heat waves. This is likely to continue this year in the middle of the COVID-19 pandemic. Managing disaster risks amid the COVID19 requires very different approaches from what used to be done. As the South Asian monsoon season begins, the spread of COVID-19 is also peaking, and more than 70 percent of the total confirmed COVID-19 cases are reported within the last one month in South Asia. The recent cyclones, Amphan and Nisarga, as well as desert locust swarms in the midst of the COVID-19 signal the complexities of cascading risks. Therefore, ESCAP’s framework to support the socioeconomic response of Asia and the Pacific to the COVID-19 pandemic highlights protecting people and enhancing resilience as one of the key priorities.