Following the adoption of resolution WHA73.8 in November 2020, on strengthening preparedness for health emergencies: implementation of the International Health Regulations (2005), the Officers of the Executive Board proposed that the Director-General prepare a report on strengthening WHO’s global emergency preparedness and response for consideration by the Board at its 148th session. As important reviews and initiatives are still in progress, the present report aims to facilitate a forward-looking discussion the opportunities for making progress on strengthening the capacity of the WHO Secretariat and Member States to fulfil their respective roles in preventing, detecting and responding to health emergencies.